Muholi was born in Durban and lives and works in Johannesburg. She co-founded the Forum for Empowerment of Women (FEW) in 2002, and in 2009 founded Inkanyiso, a forum for queer and visual (activist) media. Muholi’s self-proclaimed mission is ‘to re-write a black queer and trans visual history of South Africa for the world to know of our resistance and existence at the height of hate crimes in SA and beyond’. She continues to train and co-facilitates photography workshops for young women in the townships. An alumni of the Market Photo Workshop, Johannesburg, she completed an MFA: Documentary Media at Ryerson University, Toronto (2009) and is an Honorary Professor at the University of the Arts/Hochschule für Künste Bremen. Muholi has won numerous awards including the ICP Infinity Award for Documentary and Photojournalism (2016); Africa'Sout! Courage and Creativity Award (2016); a Prince Claus Award (2013); and many more.